Sending Drugs into the Fast Lane

Speedy drug approvals have become increasingly the norm at the FDA, a trend that began in 1992 with the passage of the Prescription Drug User Fee Act. Over the past 20 years, the approval process has shrunk, on average, from three years to ten months. As speed has risen, the number of safety issues has as well. Some notoriously harmful drugs, such as Vioxx and Avandia, that were pulled from the market because of dangerous side effects, were fast-tracked. Some doctors and industry analysts question whether the agency’s laissez faire approach is essentially moving the testing phase of drugs from the laboratory to the medicine cabinet

Application of Game Theory to Improve the Defense of the Smart Grid

This thesis presents the development and evaluation of a distributed agent based system using reputation based trust and game theoretic techniques to improve the defense of the future smart grid from cyber-attack and equipment malfunctions. Future smart grid capabilities promise to leverage network technologies to revolutionize the production, transmission, distribution and consumption of electrical power. However, the internet like communication also increase the power grid\u27s vulnerability to cyber-attack. This thesis uses simulation linking power systems with communication networks to demonstrate the benefits of a Distributed Decision Making Communication Enable Special Protection System (SPS) using reputation based trust and game theory to protect the power grid from malicious and non-malicious malfunctions. The simulations show that a distributed approach to SPS load shedding successfully maintains power grid stability after an electrical disturbance while using reputation based trust to defend the load shedding from cyber-attack and equipment malfunction. Additional simulations demonstrate the application of game theory to defend the SPS load shedding process when available resources prevent the monitoring and defense of every part of the power grid. The demonstrated capability increases the resiliency of the power grid by preventing uncontrolled blackouts through detection and mitigation of attacks, improving the system\u27s reliability

The Space of Drawing

In this essay we engage with Maurice Merleau-Ponty’s claim as it is articulated in his famous last work, ‘Eye and Mind’, that Descartes’ account of space derived from the Renaissance art of perspective. We argue that not only is this account of space an essential element of Cartesian metaphysics, but that it plays a key role in modern philosophy and modern science. In part our aim is to underscore Merleau-Ponty’s recognition of the part that art plays in the genesis of the modern conception of space. However, we also argue that by way of this recognition, Merleau-Ponty seeks to release us from the limitations of this conception of space and the view of the human subject it entails, and return us to the world upon which the acts of drawing and painting draw, namely the ambiguous world of perception replete with creative potential

The Space of Drawing: The Place of Art in Modern Philosophy's Thinking of the Visible

In this article we engage with Maurice Merleau-Ponty’s claim as it is articulated in his famous last work, ‘Eye and Mind’, that Descartes’ account of space derived from the Renaissance art of perspective. We argue that not only is this account of space an essential element of Cartesian metaphysics, but that it plays a key role in modern philosophy and modern science. In part our aim is to underscore Merleau-Ponty’s recognition of the role that art plays in the genesis of the modern conception of space. However, we also argue that by way of this recognition, Merleau-Ponty seeks to release us from the limitations of this conception of space and the view of the human subject it entails, and return us to the world upon which the acts of drawing and painting draw, namely the ambiguous world of perception replete with creative potential

AN EVALUATION OF THE KINEMATICS OF PUTTING TO ASSIST IN THE DEVELOPMENT OF FEEDBACK MECHANISM

To develop a meaningful feedback mechanism it is essential to establish what elements of the motor skill require feedback and establish if differing levels of ability require feedback on the similar elements of the putting stroke. Volunteers (n=33) were grouped according to their putting ability. A kinematic analysis (200Hz) of each volunteers putting stroke was undertaken and this data was compared to the final resting position of the ball. Results demonstrated that yaw angle is an integral component of putting accuracy for all levels of golfers while club head velocity in the direction of the putt is vital for distance control. To ensure the appropriate development of a putting feedback mechanism the putting ability of the golfer must be known, to ensure that the specific feedback been given is suitable to the golfers needs

I Know Where You are and What You are Sharing: Exploiting P2P Communications to Invade Users' Privacy

In this paper, we show how to exploit real-time communication applications to determine the IP address of a targeted user. We focus our study on Skype, although other real-time communication applications may have similar privacy issues. We first design a scheme that calls an identified targeted user inconspicuously to find his IP address, which can be done even if he is behind a NAT. By calling the user periodically, we can then observe the mobility of the user. We show how to scale the scheme to observe the mobility patterns of tens of thousands of users. We also consider the linkability threat, in which the identified user is linked to his Internet usage. We illustrate this threat by combining Skype and BitTorrent to show that it is possible to determine the file-sharing usage of identified users. We devise a scheme based on the identification field of the IP datagrams to verify with high accuracy whether the identified user is participating in specific torrents. We conclude that any Internet user can leverage Skype, and potentially other real-time communication systems, to observe the mobility and file-sharing usage of tens of millions of identified users.Comment: This is the authors' version of the ACM/USENIX Internet Measurement Conference (IMC) 2011 pape

Corporate social responsibility:reviewed, rated, revised

Purpose: Critical literature review of CSR research in both general management and hospitality management literature. Discusses trends,commonalities, and inconsistencies to better understand the state of contemporary scholarship, and calls for a context-specific conceptual engagement with the phenomenon.Design/Methodology/Approach: Systematic literature review, noting and critiquing a general tendency towards measurement of financial and other internal benefit impacts.Findings: Hospitality management is well-positioned to evaluate the opportunities and challenges of CSR, yet research has uncritically adopted the instrumental emphasis on assessing processes, perceptions, and private profitability from the general management literature, without engaging on a contextually-specific and/or theoretical level.Research limitations: CSR research is abundant and therefore difficult to summarise in one article.The primarily Anglo-American and Asian contextual bias is reflected in this review.Practical implications: Consistently inconsistent results challenge the portability of financial impact studies.Studies are needed to re-evaluate the concept of CSR as it pertains to hospitality, and measure the effectiveness of CSR activities relative to context and resource availability.Social implications: Further research into the scope of CSR in hospitality management, with an emphasis on recuperating social value, would lead to widespread positive social implications.Originality/value: This critical review offers a new perspective on CSR in the hospitality literature and industry, calling for a reconsideration of the concept in context, and formulates a working definition